Alanine methyl ester hydrochloride → HCID 45111377, compound

HRID 468593Notes

Reaction equation

HRID 468593 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[N:4]=[C:5]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([C@H:15]([CH3:19])[C:16]([OH:18])=O)=[CH:11][CH:10]=2)[O:6][CH:7]=1.Cl.C[O:24][C:25](=[O:29])[C@H:26]([CH3:28])[NH2:27]>>[F:20][C:2]([F:1])([F:21])[C:3]1[N:4]=[C:5]([NH:8][C:9]2[CH:10]=[CH:11][C:12]([C@H:15]([CH3:19])[C:16]([NH:27][C@@H:26]([CH3:28])[C:25]([OH:29])=[O:24])=[O:18])=[CH:13][CH:14]=2)[O:6][CH:7]=1

Participants

3

Reactant 2

HCID 2733257Alanine methyl ester hydrochlorideHCID 58409170HCID 58409170, compound

Product 1

HCID 45111377HCID 45111377, compoundYield 74.4%

Procedure

Following the same procedure described for 16 and starting from (2S)-2-(4-{[4-(trifluoromethyl)-1,3-oxazol-2-yl]amino}phenyl)propanoic acid (19) (0.118 g, 0.39 mmol) and L-alanine methyl ester hydrochloride (0.035 g, 0.39 mmol), after workup and methyl ester hydrolysis, pure compound 24 (0.112 g, 0.29 mmol) was isolated as pale yellow oil (75%).

Sources & evidence

ORD record
ord-1a122a0af61b40f6a81de3a031456186
Source dataset
uspto-grants-2014_01
Patent number
US08624036B2

Reaction notes

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