Hydrochloric Acid → HCID 16219018, compound

HRID 468697Notes

Reaction equation

HRID 468697 reaction equation
[NH2:1][C@H:2]([C:5]([OH:7])=[O:6])[CH2:3][SH:4].[CH3:8][C:9](O)([CH3:11])[CH3:10].[ClH:13]>>[ClH:13].[NH2:1][CH:2]([CH2:3][S:4][C:9]([CH3:11])([CH3:10])[CH3:8])[C:5]([OH:7])=[O:6]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 5862L-(+)-CysteineHCID 6386tert-Butanol

Product 1

HCID 16219018HCID 16219018, compoundYield 84%

Procedure

A solution of L-cysteine (30.3 g, 0.25 mol) and t-BuOH (62.2 mL, 0.65 mol) in 2N HCl (110 mL) was heated at 120° C. in a sealed flask for 48 h. After cooling, it was concentrated to dryness and triturated with acetone to give 14 as a white solid (45.0 g, 84%). 1H NMR (400 MHz, DMSO-d6) δ 8.58 (br s, 3H), 4.06 (t, 1H), 3.03 (m, 2H), 1.29 (s, 9H).

Workup

  1. temperatureAfter cooling
  2. concentrationit was concentrated to dryness
  3. customtriturated with acetone

Sources & evidence

ORD record
ord-003f42659e2f48859457e7950da8ffaa
Source dataset
uspto-grants-2014_01
Patent number
US08624052B2

Reaction notes

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