5-tert-Butoxycarbonylamino-2-chloroisonicotinic acid → HCID 86674948, compound

HRID 468847Notes

Reaction equation

HRID 468847 reaction equation
C(OC([NH:8][C:9]1[C:14]([C:15](O)=[O:16])=[CH:13][C:12]([Cl:18])=[N:11][CH:10]=1)=O)(C)(C)C.[F:19][C:20]1[CH:21]=[CH:22][C:23]([CH3:29])=[C:24]([C:26](=O)[CH3:27])[CH:25]=1>>[Cl:18][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][N:11]=1)[NH:8][C:26]([C:24]1[CH:25]=[C:20]([F:19])[CH:21]=[CH:22][C:23]=1[CH3:29])=[CH:27][C:15]2=[O:16]

Participants

3

Reactant 2

HCID 105641445-tert-Butoxycarbonylamino-2-chloroisonicotinic acidHCID 153354201-(5-Fluoro-2-methylphenyl)ethan-1-one

Product 1

HCID 86674948HCID 86674948, compoundYield 24%

Procedure

The title compound was prepared following a procedure similar to example 121 using 5-(tert-butoxycarbonylamino)-2-chloroisonicotinic acid (505 mg, 1.85 mmol) and 5′-fluoro-2′-methylacetophenone (566 mg, 3.72 mmol) to afford the impure title compound as a beige solid (128 mg), used without further purification. LCMS: M+H+=289 & 291.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-ce8c7e5988fa43c395425994c5f715fa
Source dataset
uspto-grants-2014_01
Patent number
US08623889B2

Reaction notes

Loading…