Lithium Hydroxide → HCID 57950908, compound

HRID 468905Notes

Reaction equation

HRID 468905 reaction equation
[CH2:1]([O:3][CH:4]1[CH2:6][CH:5]1[C:7]([O:9]CC)=[O:8])[CH3:2].[OH-].[Li+:13]>CO>[Li+:13].[CH2:1]([O:3][CH:4]1[CH2:6][CH:5]1[C:7]([O-:9])=[O:8])[CH3:2]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 12731313HCID 12731313, compound

Product 1

HCID 57950908HCID 57950908, compoundYield 104%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of the crude ethyl 2-ethoxycyclopropanecarboxylate in methanol (10 mL) was treated with aqueous lithium hydroxide (8.6 mL, 1.0 M, 8.6 mmol, 1.0 equiv.), the mixture stirred at ambient temperature for 16 h, and concentrated in vacuo. The resulting orange syrup was twice redissolved in methanol and concentrated in vacuo to afford crude 2-ethoxycyclopropane-carboxylic acid lithium salt as an orange foam (1.21 g, 104%).

Workup

  1. concentrationconcentrated in vacuo
  2. dissolutionThe resulting orange syrup was twice redissolved in methanol
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-9ddfe8811f33443d99c338faa4ac3a90
Source dataset
uspto-grants-2014_01
Patent number
US08623889B2

Reaction notes

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