Di-tert-butyl dicarbonate → HCID 86593479, compound

HRID 468979Notes

Reaction equation

HRID 468979 reaction equation
[C:1]([O:8][C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]>C(Cl)Cl>[CH3:7][C:4]([O:3][C:1]([O:8][C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])=[O:2])([CH3:5])[CH3:6].[C:12]([O:11][C:9]([O:8][C:1]([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2])=[O:10])([CH3:15])([CH3:14])[CH3:13]

Participants

3

Reactant 1

HCID 90495Di-tert-butyl dicarbonate

Product 1

HCID 86593479HCID 86593479, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of amine (1.0 eq), TEA (2 eq) in DCM (25 vol) was added di-tert-butyl dicarbonate, (1.1 eq). The mixture was stirred overnight at ambient temperature. The mixture was concentrated in vacuo and purified by FCC eluting with EtOAc:Heptane, 1:3.

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. custompurified by FCC
  3. washeluting with EtOAc

Sources & evidence

ORD record
ord-9f07095973df40648557ef9dfcee6bb9
Source dataset
uspto-grants-2014_01
Patent number
US08623859B2

Reaction notes

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