Hydrochloric Acid → 5-bromo-2,3-dihydro-1H-inden-1-ol

5-bromo-2,3-dihydro-1H-inden-1-one (2.0 g) was dissolved in methanol (20 mL), and to the resultant solution, sodium borohydride (0.54 g) was added at room temperature, followed by stirring the resultant reaction mixture at room temperature for 14 hours. To the reaction mixture, 1M hydrochloric acid (50 mL) was added, followed by extracting the resultant reaction mixture with ethyl acetate (50 mL) three times, and the organic phase was washed sequentially with water (50 mL) and a saturated saline (50 mL) and was dried over anhydrous sodium sulfate. From the organic phase, the solvent was distilled off under reduced pressure to obtain the subject compound (2.0 g) as a pale yellow solid.

1. customreaction mixture at room temperature for 14 hours
2. extractionby extracting the resultant
3. customreaction mixture with ethyl acetate (50 mL) three times
4. washthe organic phase was washed sequentially with water (50 mL)
5. dry with materiala saturated saline (50 mL) and was dried over anhydrous sodium sulfate
6. distillationFrom the organic phase, the solvent was distilled off under reduced pressure

ORD record

ord-10cb1f4f0d3c4988ba3d4031e0193416

Source dataset

uspto-grants-2014_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08629102B2