Water ethanol → 2,2-Difluoro-2-(quinolin-6-yl)acetohydrazide

HRID 469187Notes

Reaction equation

HRID 469187 reaction equation
[F:1][C:2]([F:28])([C:13]1N2N=C(C3C=NN(C)C=3)C=CC2=[N:15][N:14]=1)[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[CH:6]2.C([OH:31])C.O>>[F:1][C:2]([F:28])([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][CH:7]=[CH:6]2)[C:13]([NH:14][NH2:15])=[O:31]

Participants

3

Reactant 2

HCID 19096565Water ethanolHCID 469118636-(Difluoro(6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo(4,3-b)pyridazin-3-yl)methyl)quinoline

Product 1

HCID 589552502,2-Difluoro-2-(quinolin-6-yl)acetohydrazide

Procedure

Form I of the compound of formula (I) (0.5 g, as prepared in Example 1) is heated at 60° C. in acetone/water mixture (50/50, vol/vol; 12 mL) for 1 hour. The solids are filtered and dried at 50° C. to provide 0.48 g of Form III.

Workup

  1. filtrationThe solids are filtered
  2. customdried at 50° C.

Sources & evidence

ORD record
ord-f7993ef9b878477eb6f434a8b096c463
Source dataset
uspto-grants-2014_01
Patent number
US08629144B2

Reaction notes

Loading…