HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water ethanol → 2,2-Difluoro-2-(quinolin-6-yl)acetohydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water ethanol | HCID 19096565 | — |
| Reactant | 6-(Difluoro(6-(1-methyl-1H-pyrazol-4-yl)-1,2,4-triazolo(4,3-b)pyridazin-3-yl)methyl)quinoline | HCID 46911863 | — |
| Product | 2,2-Difluoro-2-(quinolin-6-yl)acetohydrazide | HCID 58955250 | — |
Reaction Steps
Form I of the compound of formula (I) (0.5 g, as prepared in Example 1) is heated at 60° C. in acetone/water mixture (50/50, vol/vol; 12 mL) for 1 hour. The solids are filtered and dried at 50° C. to provide 0.48 g of Form III.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629144B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-f7993ef9b878477eb6f434a8b096c463 |
| Source note | uspto-grants-2014_01 |