Hydrochloric Acid → HCID 20151416, compound

HRID 4692Notes

Reaction equation

HRID 4692 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=[C:4]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-:22])=[O:21])[CH:15]=2)[C:3]=1[CH2:23][N:24]1[CH2:29][CH2:28][N:27]([CH:30]=[O:31])[CH2:26][CH2:25]1.[ClH:32]>CO>[ClH:32].[CH3:1][C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=[C:4]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-:22])=[O:21])[CH:15]=2)[C:3]=1[CH2:23][N:24]1[CH2:29][CH2:28][N:27]([CH:30]=[O:31])[CH2:26][CH2:25]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10093416HCID 10093416, compound

Product 1

HCID 20151416HCID 20151416, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
10 °C

Procedure

A mixture of 6-methyl-5-(4-formylpiperazin-1-ylmethyl)-4-(3-nitrophenyl)-2-phenylpyrimidine (4.5 g) and hydrochloric acid (2 ml) in methyl alcohol (45 ml) was stirred at 10° C. for 2 hours. The resulting precipitates were collected by filtration, washed with methyl alcohol and dried in vacuo to give 6-methyl-5-(4-formylpiperazin-1-ylmethyl)-4-(3-nitrophenyl)-2-phenylpyrimidine hydrochloride (4.14 g).

Workup

  1. customThe resulting precipitates
  2. filtrationwere collected by filtration
  3. washwashed with methyl alcohol
  4. customdried in vacuo

Sources & evidence

ORD record
ord-03a3e9fdc377495d8579edee92e18c46
Source dataset
uspto-grants-1988_02
Patent number
US04727073

Reaction notes

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