Hydrochloric Acid → HCID 86679326, compound

HRID 469281Notes

Reaction equation

HRID 469281 reaction equation
[Br:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:39]=[CH:38][C:9]([CH2:10][NH:11][C:12]2[N:17]=[C:16]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])[N:15]=[C:14]([NH:24][C:25]3[CH:37]=[CH:36][C:28]([C:29]([O:31]C(C)(C)C)=[O:30])=[CH:27][CH:26]=3)[CH:13]=2)=[CH:8][CH:7]=1.Cl>O1CCOCC1>[Br:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]([CH2:10][NH:11][C:12]2[N:17]=[C:16]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])[N:15]=[C:14]([NH:24][C:25]3[CH:26]=[CH:27][C:28]([C:29]([OH:31])=[O:30])=[CH:36][CH:37]=3)[CH:13]=2)=[CH:38][CH:39]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86679327HCID 86679327, compound

Product 1

HCID 86679326HCID 86679326, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Tert-butyl 4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzoate (90 mg, 0.15 mmol) and 4 N HCl in dioxane (2 mL) were stirred for 10 mins then concentrated under vacuum to give 4-((6-((4-(3-bromopropoxy)benzyl)amino)-2-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzoic acid which was carried to the next step without purification.

Workup

  1. concentrationthen concentrated under vacuum

Sources & evidence

ORD record
ord-ec3f608c92ee47f7b5b02530afc66855
Source dataset
uspto-grants-2014_01
Patent number
US08629150B2

Reaction notes

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