反应详情

63.5 g (287 mmol) sodium diethyl-oxalacetate and 30.2 g (287 mmol) formamidine acetate were added to 24.1 g (597 mmol) NaOH in 3.6 L water. The mixture was stirred overnight at RT. Then activated charcoal was added and the mixture was refluxed for 1 h. It was filtered hot and after cooling acidified with aqueous HCl. The solution was concentrated to dryness by rotary evaporation. The residue contained the desired product and was used in the next step without further purification.

1. temperaturethe mixture was refluxed for 1 h
2. filtrationIt was filtered hot
3. temperatureafter cooling
4. concentrationThe solution was concentrated to dryness by rotary evaporation
5. customwas used in the next step without further purification