反应详情

801 mg (6.00 mmol) N-chlorosuccinimide were added to 1.23 g (5.00 mmol) 3-piperidin-4-yl-1,3,4,5-tetrahydro-benzo[d][1,3]diazepin-2-one in 10.0 mL carbon tetrachloride and the mixture was refluxed for 72 h. The solvent was eliminated i. vac. and the crude product was purified by flash chromatography. The fractions containing the product were concentrated by rotary evaporation and purified by preparative HPLC.

1. temperaturethe mixture was refluxed for 72 h
2. customand the crude product was purified by flash chromatography
3. additionThe fractions containing the product
4. concentrationwere concentrated by rotary evaporation
5. custompurified by preparative HPLC