反应详情

3.00 g (14.3 mmol) 2,6-dichloropyridine-4-carboxylic acid chloride, 1.80 g (11.0 mmol) 4-methyl-3H-benzoxazol-2-one and 9.47 g (71.0 mmol) aluminium trichloride were combined and heated for 2 h to 125° C. with stirring. Then the mixture was decomposed with ice water and EtOAc and the phases were separated. The aqueous phase was extracted several times with EtOAc. The organic phases were combined, dried on sodium sulphate, filtered and the filtrate was evaporated down i. vac. The residue was triturated with diethyl ether, the precipitate was suction filtered and dried i. vac.

1. temperatureheated for 2 h to 125° C.
2. customthe phases were separated
3. extractionThe aqueous phase was extracted several times with EtOAc
4. customdried on sodium sulphate
5. filtrationfiltered
6. customthe filtrate was evaporated down i
7. customThe residue was triturated with diethyl ether
8. filtrationfiltered
9. customdried i