反应详情

Under a nitrogen atmosphere and while cooling with ice 220 mg (5.06 mmol) sodium hydride (55%, suspension in mineral oil) were added to 2.00 g (5.07 mmol) 6-(2-benzyloxy-6-chloro-pyridine-4-carbonyl)-4-methyl-3H-benzoxazol-2-one in 10 mL DMF. The reaction mixture was stirred for 30 min at RT. Then 0.312 mL (5.06 mmol) iodomethane were added and the mixture was stirred overnight at RT. The reaction mixture was poured onto water and the precipitated product was suction filtered, washed with water and dried. The residue was stirred with diethyl ether, suction filtered and dried.

1. stirringthe mixture was stirred overnight at RT
2. additionThe reaction mixture was poured onto water
3. filtrationfiltered
4. washwashed with water
5. customdried
6. stirringThe residue was stirred with diethyl ether, suction
7. filtrationfiltered
8. customdried