Thionyl Chloride → 5-Bromo-nicotinic acid chloride hydrochloride

HRID 469325Notes

Reaction equation

HRID 469325 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7](O)=[O:8].S(Cl)([Cl:13])=O>>[ClH:13].[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([Cl:13])=[O:8]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 887075-Bromonicotinic acid

Product 1

HCID 189717365-Bromo-nicotinic acid chloride hydrochloride

Procedure

2.00 g (9.90 mmol) 5-bromonicotinic acid were mixed with 20 mL thionyl chloride and boiled for 4 h. The mixture was evaporated to dryness i. vac. and coevaporated twice with toluene. The residue was reacted further as the crude product.

Workup

  1. customThe mixture was evaporated to dryness i
  2. customThe residue was reacted further as the crude product

Sources & evidence

ORD record
ord-aec1b31938f64749be5586e273bf77b8
Source dataset
uspto-grants-2014_01
Patent number
US08629137B2

Reaction notes

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