HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 5-Bromo-nicotinic acid chloride hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 5-Bromonicotinic acid | HCID 88707 | — |
| Product | 5-Bromo-nicotinic acid chloride hydrochloride | HCID 18971736 | — |
Reaction Steps
2.00 g (9.90 mmol) 5-bromonicotinic acid were mixed with 20 mL thionyl chloride and boiled for 4 h. The mixture was evaporated to dryness i. vac. and coevaporated twice with toluene. The residue was reacted further as the crude product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629137B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-aec1b31938f64749be5586e273bf77b8 |
| Source note | uspto-grants-2014_01 |