Aluminum(III) Chloride → 6-(5-bromo-pyridin-3-carbonyl)-4-methyl-3H-benzoxazol-2-one

Participants

Reaction Steps

2.57 g (10.0 mmol) 5-bromo-nicotinic acid chloride hydrochloride, 1.49 g (10.0 mmol) 4-methyl-3H-benzoxazol-2-one and 5.33 g (40.0 mmol) aluminium trichloride were heated to 125° C. with stirring for 1.5 h. After cooling to RT the mixture was mixed with ice water. The precipitate formed was suction filtered, washed with water and dried i. vac.

Provenance & Evidence