HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 3,5-Difluorobenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 3,5-Difluorobenzoic acid | HCID 101265 | — |
| Product | 3,5-Difluorobenzoyl chloride | HCID 145600 | — |
Reaction Steps
1.63 g (10.00 mmol) 3,5-difluoro-benzoic acid were mixed with 20 mL thionyl chloride and boiled for 2 h. The reaction mixture was evaporated to dryness and coevaporated twice with toluene. The residue was reacted further as the crude product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08629137B2 |
| Source dataset | uspto-grants-2014_01 |
| ORD ID | ord-a565cd0d833a42f3b36e645c6b592ea7 |
| Source note | uspto-grants-2014_01 |