Thionyl Chloride → 4-Cyano-3-fluorobenzoyl chloride

HRID 469341Notes

Reaction equation

HRID 469341 reaction equation
[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7](O)=[O:8])=[CH:5][C:4]=1[F:12])#[N:2].S(Cl)([Cl:15])=O>>[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([Cl:15])=[O:8])=[CH:5][C:4]=1[F:12])#[N:2]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 27784684-Cyano-3-fluorobenzoic acid

Product 1

HCID 199567394-Cyano-3-fluorobenzoyl chloride

Procedure

0.66 g (4.0 mmol) 4-cyano-3-fluoro-benzoic acid were mixed with 10 mL thionyl chloride and boiled for 2 h. The mixture was evaporated to dryness and coevaporated twice with toluene. The residue was reacted further as the crude product.

Workup

  1. customThe mixture was evaporated to dryness
  2. customThe residue was reacted further as the crude product

Sources & evidence

ORD record
ord-5d904c35d39c4e24855c8b7d93a46084
Source dataset
uspto-grants-2014_01
Patent number
US08629137B2

Reaction notes

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