HCID 59856530, compound → HCID 59856532, compound

HRID 469352Notes

Reaction equation

HRID 469352 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[C:18]=2[N+:24]([O-])=O)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO>[NH2:24][C:18]1[C:19]([F:23])=[CH:20][CH:21]=[CH:22][C:17]=1[CH2:16][CH2:15][NH:14][CH:11]1[CH2:12][CH2:13][N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9][CH2:10]1

Participants

3

Reactant 1

HCID 59856530HCID 59856530, compound

Product 1

HCID 59856532HCID 59856532, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

14.4 g (40.3 mmol) (1-benzyl-piperidin-4-yl)-[2-(3-fluoro-2-nitro-phenyl)-ethyl]-amine in 100 mL MeOH were stirred with 2.00 g rhodium charcoal (10%) and shaken at RT under a hydrogen atmosphere (3 bar). The catalyst was filtered off and the solvent was eliminated i. vac. The residue was further reacted immediately as the crude product.

Workup

  1. filtrationThe catalyst was filtered off
  2. customThe residue was further reacted immediately as the crude product

Sources & evidence

ORD record
ord-642e372b9bfe44099f0a13a53271c40f
Source dataset
uspto-grants-2014_01
Patent number
US08629137B2

Reaction notes

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