HRID469360

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID18356852

未命名化合物

结构：Cc1cc(C(=O)c2cc(Cl)nc(OCc3ccccc3)c2)cc2oc(=O)n(C)c12

HCID58181106

未命名化合物

PRODUCTS

生成物

结构：COc1ccc2c(c1)CCN(C1CCN(c3cc(C(=O)c4cc(C)c5c(c4)oc(=O)n5C)cc(OCc4ccccc4)n3)CC1)C(=O)N2

HCID58181145

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

CONDITIONS

反应条件

温度: 120 °C

PROCEDURE

实验过程

991 mg (3.60 mmol) 7-methoxy-3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one and 500 mg (1.22 mmol) 6-(2-benzyloxy-6-chloro-pyridine-4-carbonyl)-3,4-dimethyl-3H-benzoxazol-2-one were combined in 10 mL NMP and stirred overnight at 120° C. The reaction mixture was purified by preparative HPLC-MS. The fractions containing the product were combined and evaporated down.

WORKUP

后处理

customThe reaction mixture was purified by preparative HPLC-MS
additionThe fractions containing the product
customevaporated down

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a24ac539a47943eaa52dc104de08a810
来源数据集: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08629137B2
来源说明: uspto-grants-2014_01

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11](=[O:13])[N:10]([CH:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[CH2:9][CH2:8][C:7]=2[CH:20]=1.[CH2:21]([O:28][C:29]1[CH:34]=[C:33]([C:35]([C:37]2[CH:47]=[C:46]([CH3:48])[C:40]3[N:41]([CH3:45])[C:42](=[O:44])[O:43][C:39]=3[CH:38]=2)=[O:36])[CH:32]=[C:31](Cl)[N:30]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>CN1C(=O)CCC1>[CH2:21]([O:28][C:29]1[N:30]=[C:31]([N:17]2[CH2:18][CH2:19][CH:14]([N:10]3[CH2:9][CH2:8][C:7]4[CH:20]=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][C:6]=4[NH:12][C:11]3=[O:13])[CH2:15][CH2:16]2)[CH:32]=[C:33]([C:35]([C:37]2[CH:47]=[C:46]([CH3:48])[C:40]3[N:41]([CH3:45])[C:42](=[O:44])[O:43][C:39]=3[CH:38]=2)=[O:36])[CH:34]=1)[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1