7-methoxy-3-(piperidin-4-yl)-4,5-dihydro-1H-benzo[d][1,3]diazepin-2(3H)-one → HCID 25270132, compound

HRID 469402Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11](=[O:13])[N:10]([CH:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[CH2:9][CH2:8][C:7]=2[CH:20]=1.[F:21][C:22]1[CH:23]=[C:24]([CH:39]=[C:40](F)[CH:41]=1)[C:25]([C:27]1[CH:37]=[C:36]([CH3:38])[C:30]2[N:31]([CH3:35])[C:32](=[O:34])[O:33][C:29]=2[CH:28]=1)=[O:26]>CN(C=O)C>[CH3:35][N:31]1[C:30]2[C:36]([CH3:38])=[CH:37][C:27]([C:25]([C:24]3[CH:39]=[C:40]([N:17]4[CH2:18][CH2:19][CH:14]([N:10]5[CH2:9][CH2:8][C:7]6[CH:20]=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][C:6]=6[NH:12][C:11]5=[O:13])[CH2:15][CH2:16]4)[CH:41]=[C:22]([F:21])[CH:23]=3)=[O:26])=[CH:28][C:29]=2[O:33][C:32]1=[O:34]

Participants

Conditions

Temperature: 300 °C

Procedure

440 mg (1.60 mmol) 7-methoxy-3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one and 121 mg (0.40 mmol) 6-(3,5-difluoro-benzoyl)-3,4-dimethyl-3H-benzoxazol-2-one were combined and heated to 300° C. for approx. 10 min using the hot gun. Then the mixture was dissolved in DMF and purified by preparative HPLC-MS. The fractions containing the product were combined and the organic solvent was evaporated down. The residue was neutralised with 1N aqueous sodium hydroxide solution, the precipitate formed was suction filtered, washed with water and dried i. vac.

Workup

custompurified by preparative HPLC-MS
additionThe fractions containing the product
customthe organic solvent was evaporated down
customthe precipitate formed
filtrationfiltered
washwashed with water
customdried i

Sources & evidence

ORD record: ord-c41a9165bad04bfb977667b1e21a00dd
Source dataset: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08629137B2

Reaction notes

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