HRID469416

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID962

Water

H2O

HCID58181102

未命名化合物

结构：Cc1cc(C(=O)c2cc(Cl)ncn2)cc2oc(=O)n(C)c12

HCID58181162

未命名化合物

PRODUCTS

生成物

结构：COc1ccc2[nH]c(=O)c(C3CCN(c4cc(C(=O)c5cc(C)c6c(c5)oc(=O)n6C)ncn4)CC3)cc2c1

HCID25270814

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

30 mg (0.087 mmol) 6-methoxy-3-piperidin-4-yl-1H-quinoline-2-one, 30 mg (0.10 mmol) 6-(6-chloro-pyrimidine-4-carbonyl)-3,4-dimethyl-3H-benzoxazol-2-one and 50 μl (0.36 mmol) TEA were combined in 3 mL DMF and stirred overnight at RT. Then the reaction mixture was added to water, the precipitate formed was suction filtered and washed with MeOH. Next, the precipitate was boiled in DMF/MeOH and the precipitate was suction filtered.

WORKUP

后处理

customthe precipitate formed
filtrationfiltered
washwashed with MeOH
filtrationfiltered

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f4e3d3a54fbc459eb31643249c6dbb57
来源数据集: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08629137B2
来源说明: uspto-grants-2014_01

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8](=[O:13])[C:7]([CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1)=[CH:6]2.Cl[C:21]1[N:26]=[CH:25][N:24]=[C:23]([C:27]([C:29]2[CH:39]=[C:38]([CH3:40])[C:32]3[N:33]([CH3:37])[C:34](=[O:36])[O:35][C:31]=3[CH:30]=2)=[O:28])[CH:22]=1.O>CN(C=O)C>[CH3:37][N:33]1[C:32]2[C:38]([CH3:40])=[CH:39][C:29]([C:27]([C:23]3[N:24]=[CH:25][N:26]=[C:21]([N:17]4[CH2:18][CH2:19][CH:14]([C:7]5[C:8](=[O:13])[NH:9][C:10]6[C:5]([CH:6]=5)=[CH:4][C:3]([O:2][CH3:1])=[CH:12][CH:11]=6)[CH2:15][CH2:16]4)[CH:22]=3)=[O:28])=[CH:30][C:31]=2[O:35][C:34]1=[O:36]