反应详情

温度

120 °C

785 mg (3.60 mmol) 1-piperidin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one and 500 mg (1.22 mmol) 6-(2-benzyloxy-6-chloro-pyridine-4-carbonyl)-3,4-dimethyl-3H-benzoxazol-2-one (mixture) were combined in 5 mL NMP and stirred overnight at 120° C. The reaction mixture was purified by preparative HPLC. The fractions containing the product were combined and evaporated down. The residue was triturated with DIPE, suction filtered, washed with DIPE and dried.

1. customThe reaction mixture was purified by preparative HPLC
2. additionThe fractions containing the product
3. customevaporated down
4. customThe residue was triturated with DIPE, suction
5. filtrationfiltered
6. washwashed with DIPE
7. customdried