Ethyl 3-aminobenzoate → HCID 67124900, compound

HRID 469487Notes

Reaction equation

HRID 469487 reaction equation
[S:1]1[CH:5]=[C:4](B(O)O)[C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2.O.O=[CH:15][C:16]([OH:18])=[O:17].[NH2:19][C:20]1[CH:21]=[C:22]([CH:28]=[CH:29][CH:30]=1)[C:23]([O:25][CH2:26][CH3:27])=[O:24]>C(#N)C>[S:1]1[CH:5]=[C:4]([CH:15]([NH:19][C:20]2[CH:30]=[CH:29][CH:28]=[C:22]([C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH:21]=2)[C:16]([OH:18])=[O:17])[C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2

Participants

5

Reactant 3

HCID 11400Ethyl 3-aminobenzoateHCID 2776344(1-Benzothiophen-3-yl)boronic acidHCID 15620607Glyoxylic acid, monohydrate

Product 1

HCID 67124900HCID 67124900, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of benzo[b]thiophen-3-ylboronic acid (500 mg, 2.81 mmol) and 2-oxoacetic acid hydrate (259 mg, 2.81 mmol) in acetonitrile (20 ml), was added ethyl 3-aminobenzoate (419 μl, 2.81 mmol). The reaction was stirred at r.t. for 72 hours, and then the solvent was evaporated under vacuum. The residue was used in the next step without any further purification.

Workup

  1. customthe solvent was evaporated under vacuum
  2. customThe residue was used in the next step without any further purification

Sources & evidence

ORD record
ord-dafa6833769940f9a2cd586de248690d
Source dataset
uspto-grants-2014_01
Patent number
US08629160B2

Reaction notes

Loading…