HRID46949

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9845

Trifluoroacetic anhydride

C4F6O3

结构：CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O

HCID5280723

Alprostadil

C20H34O5

PRODUCTS

生成物

结构：CCCCC[C@H](O)/C=C/[C@H]1C=CC(=O)[C@@H]1CCCCCCC(=O)O

HCID5281912

Prostaglandin A1

C20H32O4

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

Alternately, the PGE1 -type compound is transformed to a bis-trifluoroacetate, for example by reaction with trifluoroacetic anhydride in the presence of pyridine in a solvent at 0° to 5° C., and thereafter contacted with a low-boiling alcohol (preferably b.p. below 110° C.) with a tertiary amine to form a PGA1 -type compound.