3,5-Difluorophenylacetic acid → HCID 53237281, compound

HRID 469535Notes

Reaction equation

HRID 469535 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([Cl:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:13].[F:14][C:15]1[CH:16]=[C:17]([CH2:22][C:23](O)=[O:24])[CH:18]=[C:19]([F:21])[CH:20]=1>>[Cl:12][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](=[O:13])[N:2]([NH:1][C:23](=[O:24])[CH2:22][C:17]2[CH:16]=[C:15]([F:14])[CH:20]=[C:19]([F:21])[CH:18]=2)[N:11]=1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 67160580HCID 67160580, compound

Product 1

HCID 53237281HCID 53237281, compound

Procedure

The product from Example 19A and 2-(3,5-difluorophenyl)acetic acid were processed using a method similar to that described in Example 17C to afford the title compound. 1H NMR (500 MHz, DMSO-d6) δ ppm 3.77 (s, 2H) 7.06-7.22 (m, 3H) 7.98-8.20 (m, 3H) 8.37 (d, J=7.32 Hz, 1H) 11.82 (s, 1H); MS (ESI) m/z 350 (M+H)+.

Sources & evidence

ORD record
ord-a297b2266239448fae0b7ae9bbcf6b1f
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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