(4-Chlorophenyl)acetic acid → HCID 53237495, compound

HRID 469538Notes

Reaction equation

HRID 469538 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([CH:12]2[CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:15].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][C:24](O)=[O:25])=[CH:19][CH:18]=1>>[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][C:24]([NH:1][N:2]2[N:11]=[C:10]([CH:12]3[CH2:13][CH2:14]3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:15])=[O:25])=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 15880(4-Chlorophenyl)acetic acidHCID 67160099HCID 67160099, compound

Product 1

HCID 53237495HCID 53237495, compound

Procedure

The product from Example 22B and 2-(4-chlorophenyl)acetic acid were processed using a method similar to that described in Example 17C to afford the title compound. 1H NMR (500 MHz, DMSO-d6) δ ppm 0.79-0.92 (m, 2H) 0.92-1.07 (m, 2H) 2.45-2.55 (m, 1H) 3.67 (s, 2H) 7.32-7.52 (m, 4H) 7.92 (t, J=8.09 Hz, 1H) 7.99-8.14 (m, 1H) 8.31 (t, J=7.32 Hz, 2H) 11.50 (s, 1H); MS (ESI) m/z 354 (M+H)+.

Sources & evidence

ORD record
ord-3bca79519107420c9a10cc7556a3645f
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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