3,5-Difluorophenylacetic acid → HCID 53237498, compound

HRID 469539Notes

Reaction equation

HRID 469539 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([CH:12]2[CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:15].[F:16][C:17]1[CH:18]=[C:19]([CH2:24][C:25](O)=[O:26])[CH:20]=[C:21]([F:23])[CH:22]=1>>[CH:12]1([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:15])[N:2]([NH:1][C:25](=[O:26])[CH2:24][C:19]3[CH:18]=[C:17]([F:16])[CH:22]=[C:21]([F:23])[CH:20]=3)[N:11]=2)[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 67160099HCID 67160099, compound

Product 1

HCID 53237498HCID 53237498, compound

Procedure

The product from Example 22B and 2-(3,5-difluorophenyl)acetic acid were processed using a method similar to that described in Example 17C to afford the title compound. 1H NMR (500 MHz, DMSO-d6) δ ppm 0.79-0.94 (m, 2H) 0.93-1.09 (m, 2H) 2.42-2.55 (m, 1H) 3.73 (s, 2H) 6.95-7.29 (m, 3H) 7.92 (t, J=7.63 Hz, 1H) 7.98-8.13 (m, 1H) 8.32 (d, J=7.93 Hz, 2H) 11.56 (s, 1H); MS (ESI) m/z 356 (M+H)+.

Sources & evidence

ORD record
ord-c7f5644327f34d59b9c9e7b046801be8
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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