(4-Chlorophenyl)acetic acid → HCID 53237737, compound

HRID 469540Notes

Reaction equation

HRID 469540 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([CH3:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:13].[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][C:22](O)=[O:23])=[CH:17][CH:16]=1>>[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][C:22]([NH:1][N:2]2[N:11]=[C:10]([CH3:12])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:13])=[O:23])=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 15880(4-Chlorophenyl)acetic acidHCID 8195742-Amino-4-methyl-1(2H)-phthalazinone

Product 1

HCID 53237737HCID 53237737, compound

Procedure

The product from Example 28A and 2-(4-chlorophenyl)acetic acid were processed using a method similar to that described in Example 17C to afford the title compound. 1H NMR (500 MHz, DMSO-d6) δ ppm 2.54 (s, 3H) 3.74 (s, 2H) 6.94-7.09 (m, 1H) 7.10-7.20 (m, 3H) 7.85-7.98 (m, 1H) 7.95-8.11 (m, 2H) 8.32 (d, J=7.93 Hz, 1H) 11.47-11.69 (m, 1H); MS (ESI) m/z 328 (M+H)+.

Sources & evidence

ORD record
ord-bd2b7bd4664c4288a6329953cccd6dc6
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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