反应详情

A solution of hydrazine hydrate (0.26 mL, 4.6 mmol) and the product of example 35C (0.390 g, 1.5 mmol) in EtOH (4.5 mL) was stirred at 80° C. for 3 hours, concentrated, and chromatographed on SiO2 (3% MeOH/CH2Cl2) to give 293.5 mg of the title compound as a white solid. 1H NMR (300 MHz, DMSO-d6) δ 12.93 (s, 1H), 8.42 (dd, 1H), 7.76 (ddd, 1H), 7.53-7.63 (m, 5H), 7.32 (dd, 1H).

1. concentrationconcentrated
2. customchromatographed on SiO2 (3% MeOH/CH2Cl2)