3,5-Difluorophenylacetic acid → HCID 53237966, compound

HRID 469552Notes

Reaction equation

HRID 469552 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([F:18])[CH:8]=2)[C:3]1=[O:19].[F:20][C:21]1[CH:22]=[C:23]([CH2:28][C:29](O)=[O:30])[CH:24]=[C:25]([F:27])[CH:26]=1>>[F:20][C:21]1[CH:22]=[C:23]([CH2:28][C:29]([NH:1][N:2]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[C:9]3[C:4](=[CH:5][CH:6]=[C:7]([F:18])[CH:8]=3)[C:3]2=[O:19])=[O:30])[CH:24]=[C:25]([F:27])[CH:26]=1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 67161481HCID 67161481, compound

Product 1

HCID 53237966HCID 53237966, compound

Procedure

The product from Example 35E and 2-(3,5-difluorophenyl)acetic acid were processed using a method similar to that described in Example 17C to afford the title compound. 1H NMR (500 MHz, DMSO-d6) δ ppm 3.75 (s, 2H) 7.03-7.20 (m, 3H) 7.38 (dd, J=9.46, 2.44 Hz, 1H) 7.52-7.68 (m, 5H) 7.82 (d, J=2.44 Hz, 1H) 8.48 (d, J=3.36 Hz, 1H); MS (ESI) m/z 410 (M+H)+.

Sources & evidence

ORD record
ord-72eca1e9353948f4a0a1ac0a1a802aa2
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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