3,5-Difluorophenylacetic acid → HCID 53237969, compound

HRID 469555Notes

Reaction equation

HRID 469555 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([CH3:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:13].[F:14][C:15]1[CH:16]=[C:17]([CH2:22][C:23](O)=[O:24])[CH:18]=[C:19]([F:21])[CH:20]=1>>[F:14][C:15]1[CH:16]=[C:17]([CH2:22][C:23]([NH:1][N:2]2[N:11]=[C:10]([CH3:12])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:13])=[O:24])[CH:18]=[C:19]([F:21])[CH:20]=1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 8195742-Amino-4-methyl-1(2H)-phthalazinone

Product 1

HCID 53237969HCID 53237969, compound

Procedure

The product from Example 28A and 2-(3,5-difluorophenyl)acetic acid were processed using a method similar to that described in Example 17C to afford the title compound. 1H NMR (500 MHz, DMSO-d6) δ ppm 11.58-11.61 (m, 1H), 8.32 (d, J=7.9 Hz, 1H), 8.00-8.02 (m, 2H), 7.90-7.93 (m, 1H), 7.09-7.21 (m, 2H), 7.02-7.05 (m, 1H), 3.74 (s, 2H), 2.55 (s, 3H); MS (ESI) m/z 330 (M+H)+.

Sources & evidence

ORD record
ord-26450202992141a89bdb81c45a40e8d0
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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