2-cyclobutylacetic Acid → HCID 53238205, compound

HRID 469561Notes

Reaction equation

HRID 469561 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:16].[CH:17]1([CH2:21][C:22](O)=[O:23])[CH2:20][CH2:19][CH2:18]1>>[CH:17]1([CH2:21][C:22]([NH:1][N:2]2[N:11]=[C:10]([C:12]([F:15])([F:13])[F:14])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:16])=[O:23])[CH2:20][CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 15164112-cyclobutylacetic AcidHCID 671611112-amino-4-(trifluoromethyl)phthalazin-1(2H)-one

Product 1

HCID 53238205HCID 53238205, compound

Procedure

The product of Example 11B and 2-cyclobutylacetic acid were processed using a method similar to that described in Example 17C to afford the title compound. 1H NMR (400 MHz, DMSO) δ 11.61-11.40 (m, 1H), 8.46-8.38 (m, 1H), 8.17-8.09 (m, 1H), 8.09-7.98 (m, 2H), 2.73-2.61 (m, 1H), 2.46 (d, J=7.5, 2H), 2.15-2.01 (m, 2H), 1.93-1.70 (m, 4H); MS (ESI) m/z 326 (M+H)+.

Sources & evidence

ORD record
ord-119a74f2492847b6a81d2ffe9df5743a
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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