tert-Butylacetic acid → HCID 53238428, compound

HRID 469564Notes

Reaction equation

HRID 469564 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:16].[CH3:17][C:18]([CH3:24])([CH3:23])[CH2:19][C:20](O)=[O:21]>>[CH3:17][C:18]([CH3:24])([CH3:23])[CH2:19][C:20]([NH:1][N:2]1[N:11]=[C:10]([C:12]([F:15])([F:13])[F:14])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:16])=[O:21]

Participants

3

Reactant 2

HCID 14057tert-Butylacetic acidHCID 671611112-amino-4-(trifluoromethyl)phthalazin-1(2H)-one

Product 1

HCID 53238428HCID 53238428, compound

Procedure

The product from Example 11B and 3,3-dimethylbutanoic acid were treated using a method similar to that described in Example 57 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.43-8.46 (m, 1H), 8.13-8.16 (m, 1H), 8.03-8.09 (m, 2H), 2.23 (s, 2H), 1.07 (s, 9H); MS (ESI−) M/Z 326 (M−H)−.

Sources & evidence

ORD record
ord-057594b696e34102bd7c787474b8306c
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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