4-Mesylphenylacetic acid → HCID 53238429, compound

HRID 469565Notes

Reaction equation

HRID 469565 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:16].[CH3:17][S:18]([C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28](O)=[O:29])=[CH:23][CH:22]=1)(=[O:20])=[O:19]>>[CH3:17][S:18]([C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28]([NH:1][N:2]2[N:11]=[C:10]([C:12]([F:15])([F:13])[F:14])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:16])=[O:29])=[CH:23][CH:22]=1)(=[O:19])=[O:20]

Participants

3

Reactant 2

HCID 5723454-Mesylphenylacetic acidHCID 671611112-amino-4-(trifluoromethyl)phthalazin-1(2H)-one

Product 1

HCID 53238429HCID 53238429, compound

Procedure

The product from Example 11B and 2-[4-(methylsulfonyl)phenyl]acetic acid were treated as in Example 57 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.40-8.45 (m, 1H), 8.13-8.17 (m, 1H), 8.02-8.09 (m, 2H), 7.92-7.94 (m, 2H), 7.65-7.68 (m, 2H), 3.90 (s, 2H), 3.21 (s, 3H); MS (ESI−) M/Z 424 (M−H)−.

Sources & evidence

ORD record
ord-ba893b60f1a74d52a2aefb0eb7011029
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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