Benzenepropanoic acid → HCID 53238433, compound

HRID 469566Notes

Reaction equation

HRID 469566 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:16].[C:17]1([CH2:23][CH2:24][C:25](O)=[O:26])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[O:16]=[C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[C:10]([C:12]([F:15])([F:13])[F:14])=[N:11][N:2]1[NH:1][C:25](=[O:26])[CH2:24][CH2:23][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 107Benzenepropanoic acidHCID 671611112-amino-4-(trifluoromethyl)phthalazin-1(2H)-one

Product 1

HCID 53238433HCID 53238433, compound

Procedure

The product from Example 11B and 3-phenylpropanoic acid were treated using a method similar to that described in Example 57 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.40-8.46 (m, 1H), 8.15 (td, J=7.7, 1.4 Hz, 1H), 7.99-8.09 (m, 2H), 7.28-7.34 (m, 4H), 7.20-7.25 (m, 1H), 2.94 (t, J=7.7 Hz, 2H), 2.68 (t, J=7.7 Hz, 2H); MS (ESI−) M/Z 360 (M−H)−.

Sources & evidence

ORD record
ord-e1216d217ca4496b9c056a7ad453e8cd
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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