2-Thiopheneacetyl chloride → HCID 67160795, compound

HRID 469570Notes

Reaction equation

HRID 469570 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:16].[S:17]1[CH:21]=[CH:20][CH:19]=[C:18]1[CH2:22][C:23](Cl)=[O:24]>>[O:16]=[C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[C:10]([C:12]([F:15])([F:13])[F:14])=[N:11][N:2]1[NH:1][C:23](=[O:24])[CH2:22][C:18]1[S:17][CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 1623622-Thiopheneacetyl chlorideHCID 671611112-amino-4-(trifluoromethyl)phthalazin-1(2H)-one

Product 1

HCID 67160795HCID 67160795, compound

Procedure

The product of Example 11B and 2-(thiophen-2-yl)acetyl chloride were treated using a method similar to that described in Example 53 to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.88-11.97 (m, 1H), 8.41-8.48 (m, 1H), 8.13 (td, J=7.7, 1.6 Hz, 1H), 8.00-8.09 (m, 2H), 7.43 (dd, J=5.1, 1.3 Hz, 1H), 7.04-7.08 (m, 1H), 7.01 (dd, J=5.1, 3.5 Hz, 1H), 3.96 (d, J=0.9 Hz, 2H); MS (ESI−) M/Z 352 (M−H)−.

Sources & evidence

ORD record
ord-9bc045b1d2fc4e08b1969c5b5a64f6b8
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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