2-(5-methylthiophen-2-yl)acetic Acid → HCID 67161151, compound

HRID 469572Notes

Reaction equation

HRID 469572 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:16].[CH3:17][C:18]1[S:22][C:21]([CH2:23][C:24](O)=[O:25])=[CH:20][CH:19]=1>>[CH3:17][C:18]1[S:22][C:21]([CH2:23][C:24]([NH:1][N:2]2[N:11]=[C:10]([C:12]([F:15])([F:13])[F:14])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:16])=[O:25])=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 45271772-(5-methylthiophen-2-yl)acetic AcidHCID 671611112-amino-4-(trifluoromethyl)phthalazin-1(2H)-one

Product 1

HCID 67161151HCID 67161151, compound

Procedure

The product of Example 11B and 2-(5-methylthiophen-2-yl)acetic acid were treated using a method similar to that described in Example 5 to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.85-11.96 (m, 1H), 8.43 (d, J=6.9 Hz, 1H), 8.10-8.17 (m, 1H), 8.01-8.08 (m, 2H), 6.81 (d, J=3.4 Hz, 1H), 6.66-6.68 (m, 1H), 3.84-3.85 (bs, 2H), 2.41 (d, J=0.8 Hz, 3H); MS (ESI+) M/Z 368 (M+H)+, 385 (M+NH4)+.

Sources & evidence

ORD record
ord-1baf0b0201ea42b0aba12109e9460b39
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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