Cyclopentylacetic acid → HCID 67160272, compound

HRID 469576Notes

Reaction equation

[NH2:1][N:2]1[N:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:16].[CH:17]1([CH2:22][C:23](O)=[O:24])[CH2:21][CH2:20][CH2:19][CH2:18]1>>[C:12]([C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](=[O:16])[N:2]([NH:1][C:23](=[O:24])[CH2:22][CH:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)[N:11]=1)([CH3:13])([CH3:15])[CH3:14]

Participants

Reactant 2

HCID 71606Cyclopentylacetic acid

HCID 67161087HCID 67161087, compound

Product 1

HCID 67160272HCID 67160272, compound

Procedure

The product from Example 62A and 2-cyclopentylacetic acid were treated using a method similar to that described in Example 17C to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.18 (s, 1H), 8.39 (d, J=2.0 Hz, 2H), 7.93-8.00 (m, 1H), 7.87 (t, J=7.5 Hz, 1H), 2.20-2.31 (m, 3H), 1.74-1.90 (m, 2H), 1.47-1.70 (m, 4H), 1.47 (s, 9H), 1.17-1.33 (m, 2H); MS (ESI+) M/Z 328 (M+H)+.

Sources & evidence

ORD record: ord-36fc7cadbe114a75826f9ab2c90a00d5
Source dataset: uspto-grants-2014_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08629143B2

Reaction notes

Loading…