4-Chlorophenylacetyl chloride → HCID 67160101, compound

HRID 469578Notes

Reaction equation

HRID 469578 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:16].[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][C:25](Cl)=[O:26])=[CH:20][CH:19]=1>>[C:12]([C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](=[O:16])[N:2]([NH:1][C:25](=[O:26])[CH2:24][C:21]2[CH:22]=[CH:23][C:18]([Cl:17])=[CH:19][CH:20]=2)[N:11]=1)([CH3:13])([CH3:15])[CH3:14]

Participants

3

Reactant 2

HCID 906924-Chlorophenylacetyl chlorideHCID 67161087HCID 67161087, compound

Product 1

HCID 67160101HCID 67160101, compound

Procedure

The product from Example 62A and 2-(4-chlorophenyl)acetyl chloride were treated using a method similar to that described in Example 1C to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.54 (s, 1H), 8.38 (d, J=8.3 Hz, 1H), 8.37 (dd, J=7.7, 1.6 Hz, 1H), 7.94-8.00 (m, 1H), 7.84-7.90 (m, 1H), 7.41 (s, 4H), 3.68 (s, 2H), 1.47 (s, 9H); MS (ESI+) M/Z 370 (M+H)+.

Sources & evidence

ORD record
ord-a2e86d53973a47ad8c714e849077d9ed
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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