3,5-Difluorophenylacetic acid → HCID 67161040, compound

HRID 469580Notes

Reaction equation

HRID 469580 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([CH:12]2[CH2:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:16].[F:17][C:18]1[CH:19]=[C:20]([CH2:25][C:26](O)=[O:27])[CH:21]=[C:22]([F:24])[CH:23]=1>>[CH:12]1([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:16])[N:2]([NH:1][C:26](=[O:27])[CH2:25][C:20]3[CH:19]=[C:18]([F:17])[CH:23]=[C:22]([F:24])[CH:21]=3)[N:11]=2)[CH2:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 67162274HCID 67162274, compound

Product 1

HCID 67161040HCID 67161040, compound

Procedure

The product of Example 67A and 2-(3,5-difluorophenyl)acetic acid were processed using a method similar to that described in Example 17C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ 11.62 (s, 1H), 8.35-8.28 (m, 1H), 8.01-7.94 (m, 1H), 7.94-7.85 (m, 2H), 7.20-7.10 (m, 3H), 4.12-3.99 (m, 1H), 3.76 (s, 2H), 2.42-2.22 (m, 4H), 2.14-2.00 (m, 1H), 1.89-1.76 (m, 1H); MS (ESI) m/z 370 (M+H)+.

Sources & evidence

ORD record
ord-0ee075cdc3e44315aa7d03880038c676
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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