(4-Chlorophenyl)acetic acid → HCID 67160473, compound

HRID 469582Notes

Reaction equation

HRID 469582 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([CH:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:17].[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26](O)=[O:27])=[CH:21][CH:20]=1>>[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:25][C:26]([NH:1][N:2]2[N:11]=[C:10]([CH:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:17])=[O:27])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 15880(4-Chlorophenyl)acetic acidHCID 67161381HCID 67161381, compound

Product 1

HCID 67160473HCID 67160473, compound

Procedure

The product of Example 71A and 2-(4-chlorophenyl)acetic acid were processed using a method similar to that described in Example 17C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.52-11.54 (bs, 1H), 8.31 (dd, J=7.9, 1.3 Hz, 1H), 8.13 (d, J=8.1 Hz, 1H), 7.97-8.02 (m, 1H), 7.87-7.91 (m, 1H), 7.35-7.47 (m, 4H), 3.62-3.77 (m, 3H), 1.96-2.10 (m, 2H), 1.59-1.87 (m, 6H); MS (ESI) m/z 382 (M+H)+.

Sources & evidence

ORD record
ord-e5e14d2ff432462faf989d2f57d1eff7
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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