3,5-Difluorophenylacetic acid → HCID 67160414, compound

HRID 469583Notes

Reaction equation

HRID 469583 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([CH:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:17].[F:18][C:19]1[CH:20]=[C:21]([CH2:26][C:27](O)=[O:28])[CH:22]=[C:23]([F:25])[CH:24]=1>>[CH:12]1([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:17])[N:2]([NH:1][C:27](=[O:28])[CH2:26][C:21]3[CH:20]=[C:19]([F:18])[CH:24]=[C:23]([F:25])[CH:22]=3)[N:11]=2)[CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 1454243,5-Difluorophenylacetic acidHCID 67161381HCID 67161381, compound

Product 1

HCID 67160414HCID 67160414, compound

Procedure

The product of Example 71A and 2-(3,5-difluorophenyl)acetic acid were processed using a method similar to that described in Example 17C to afford the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 11.58-11.61 (bs, 1H), 8.33 (dd, J=7.9, 1.3 Hz, 1H), 8.14 (d, J=8.1 Hz, 1H), 7.98-8.02 (m, 1H), 7.87-7.92 (m, 1H), 7.09-7.22 (m, 3H), 3.74-3.75 (m, 2H), 3.70 (d, J=7.8 Hz, 1H), 1.97-2.11 (m, 2H), 1.59-1.94 (m, 6H); MS (ESI) m/z 384 (M+H)+.

Sources & evidence

ORD record
ord-279a061293c5455db1abb7b8d61c52e6
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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