2-Fluoro-2-phenylacetyl chloride → HCID 53239330, compound

HRID 469591Notes

Reaction equation

HRID 469591 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[F:20][CH:21]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)[C:22](Cl)=[O:23]>>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:19])[N:2]([NH:1][C:22](=[O:23])[CH:21]([F:20])[C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[N:11]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 149495282-Fluoro-2-phenylacetyl chlorideHCID 671613672-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one

Product 1

HCID 53239330HCID 53239330, compound

Procedure

The product of Example 86A and 2-fluoro-2-phenylacetyl chloride were treated using a method similar to that described in Example 1C to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 12.22 (s, 1H), 8.39-8.45 (m, 1H), 7.90-8.07 (m, 2H), 7.69-7.78 (m, 1H), 7.61-7.68 (m, 6H), 7.46-7.53 (m, 3H), 6.26 (d, J=47.1 Hz, 1H); MS (ESI+) M/Z 408 (M+H)+.

Sources & evidence

ORD record
ord-c133aa86c1c04aed981e060a1a520698
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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