(3,5-Dimethoxyphenyl)acetic acid → HCID 53239112, compound

HRID 469597Notes

Reaction equation

HRID 469597 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[CH3:20][O:21][C:22]1[CH:23]=[C:24]([CH2:30][C:31](O)=[O:32])[CH:25]=[C:26]([O:28][CH3:29])[CH:27]=1>>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:19])[N:2]([NH:1][C:31](=[O:32])[CH2:30][C:24]3[CH:23]=[C:22]([O:21][CH3:20])[CH:27]=[C:26]([O:28][CH3:29])[CH:25]=3)[N:11]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 138316(3,5-Dimethoxyphenyl)acetic acidHCID 671613672-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one

Product 1

HCID 53239112HCID 53239112, compound

Procedure

The product of Example 86A and 2-(3,5-dimethoxyphenyl)acetic acid were treated using a method similar to that described in Example 57 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.41-8.43 (m, 1H), 7.90-8.04 (m, 2H), 7.72-7.74 (m, 1H), 7.62-7.66 (m, 4H), 6.58 (d, J=2.3 Hz, 2H), 6.41 (t, J=2.3 Hz, 1H), 3.75 (s, 6H), 3.74 (s, 2H); MS (ESI−) M/Z 448 (M−H)−.

Sources & evidence

ORD record
ord-78a75cdc09964810bcab91d018159080
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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