3-(Trifluoromethyl)benzeneacetic acid → HCID 53239109, compound

HRID 469601Notes

Reaction equation

HRID 469601 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[F:20][C:21]([F:33])([F:32])[C:22]1[CH:23]=[C:24]([CH2:28][C:29](O)=[O:30])[CH:25]=[CH:26][CH:27]=1>>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:19])[N:2]([NH:1][C:29](=[O:30])[CH2:28][C:24]3[CH:25]=[CH:26][CH:27]=[C:22]([C:21]([F:32])([F:20])[F:33])[CH:23]=3)[N:11]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 676953-(Trifluoromethyl)benzeneacetic acidHCID 671613672-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one

Product 1

HCID 53239109HCID 53239109, compound

Procedure

The product of Example 86A and 2-[3-(trifluoromethyl)phenyl]acetic acid were treated using a method similar to that described in Example 57 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.40-8.43 (m, 1H), 7.93-8.04 (m, 2H), 7.72-7.79 (m, 2H), 7.57-7.70 (m, 7H), 3.84 (s, 2H); MS (ESI−) M/Z 456 (M−H)−.

Sources & evidence

ORD record
ord-a76fcd0445f64b8bbc7f8eea97232e8f
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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