Benzeneacetic acid, 4-bromo- → HCID 53238894, compound

HRID 469603Notes

Reaction equation

HRID 469603 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[Br:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28](O)=[O:29])=[CH:23][CH:22]=1>>[Br:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28]([NH:1][N:2]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=3)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:19])=[O:29])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 74654Benzeneacetic acid, 4-bromo-HCID 671613672-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one

Product 1

HCID 53238894HCID 53238894, compound

Procedure

The product of Example 86A and 2-(4-bromophenyl)acetic acid were treated using a method similar to that described in Example 57 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.40-8.44 (m, 1H), 7.93-8.04 (m, 2H), 7.72-7.75 (m, 1H), 7.60-7.67 (m, 4H), 7.54-7.57 (m, 2H), 7.34-7.36 (m, 2H), 3.69 (s, 2H); MS (ESI−) M/Z 466 (M−H)−.

Sources & evidence

ORD record
ord-e073038e58a54fb5a6c2a769c9e24a47
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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