p-Tolylacetic acid → HCID 53238889, compound

HRID 469608Notes

Reaction equation

HRID 469608 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[CH3:20][C:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28](O)=[O:29])=[CH:23][CH:22]=1>>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:19])[N:2]([NH:1][C:28](=[O:29])[CH2:27][C:24]3[CH:25]=[CH:26][C:21]([CH3:20])=[CH:22][CH:23]=3)[N:11]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 248474p-Tolylacetic acidHCID 671613672-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one

Product 1

HCID 53238889HCID 53238889, compound

Procedure

The product of Example 86A and 2-(4-methylphenyl)acetic acid were treated using a method similar to that described in Example 57 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.40-8.42 (m, 1H), 7.90-8.03 (m, 2H), 7.71-7.73 (m, 1H), 7.53-7.68 (m, 4H), 7.25-7.27 (m, 2H), 7.15-7.17 (m, 2H), 3.64 (s, 2H), 2.29 (s, 3H); MS (APCI+) M/Z 404 (M+H)+.

Sources & evidence

ORD record
ord-1cb3638ed2264562b154e45b72e22e4e
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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