Cyclopentylacetic acid → HCID 53238662, compound

HRID 469610Notes

Reaction equation

HRID 469610 reaction equation
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[CH:20]1([CH2:25][C:26](O)=[O:27])[CH2:24][CH2:23][CH2:22][CH2:21]1>>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:19])[N:2]([NH:1][C:26](=[O:27])[CH2:25][CH:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)[N:11]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 71606Cyclopentylacetic acidHCID 671613672-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one

Product 1

HCID 53238662HCID 53238662, compound

Procedure

The product of Example 86A and 2-cyclopentylacetic acid were treated using a method similar to that described in Example 57 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.40-8.43 (m, 1H), 7.88-8.04 (m, 2H), 7.73-7.75 (m, 1H), 7.59-7.69 (m, 4H), 2.33 (d, J=7.4 Hz, 2H), 2.16-2.28 (m, 1H), 1.75-1.87 (m, 2H), 1.59-1.69 (m, 2H), 1.49-1.58 (m, 2H), 1.19-1.31 (m, 2H); MS (ESI−) M/Z 380 (M−H)−.

Sources & evidence

ORD record
ord-758e8d163b054d84a6909f7ab908f4a1
Source dataset
uspto-grants-2014_01
Patent number
US08629143B2

Reaction notes

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